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  • 師資

    譚斌
    教授
    科研副系主任
    0755-88018315
    tanb@sustech.edu.cn

    譚斌是南方科技大學終身教授,化學系科研副主任、博士生導師。2001年本科畢業于湖南科技大學。2005年碩士畢業于廈門大學化學系。 2010年博士畢業于新加坡南洋理工大學化學與生物化學系,導師鐘國富教授,研究方向為新型手性有機催化劑的設計及不對稱多米諾反應的研究。2010年3月至2012 年9月的博士后期間,在有機小分子催化領域的發源地--美國斯克普斯研究所 (The Scripps Research Institute)師從Barbas教授,繼續從事催化不對稱合成的研究。2012年9月,以準聘(Tenure-Track)副教授身份加入南方科技大學化學系。2018年1月晉升為終身正教授。

    到目前為止,在軸手性化學、不對稱多組分反應、自由基化學以及協同催化領域發表高水平研究論文60多篇,其中包括以第一作者或通訊作者身份發表的1篇Science、2篇Nature Chemistry、3篇Nature Communications、 6篇J. Am. Chem. Soc.、11篇Angew. Chem. Int. Ed. 和1篇Accounts of Chemical Research,論文總被引超過4000次。多篇論文被多篇文章被不同國際雜志重點評述或被選為封面文章。此外還有多篇高水平研究論文正在審稿和準備之中。

    目前擔任《中國科學-化學》和《中國化學》青年編委。

     

    研究領域及方向

    ◆ 核心骨架結構導向的催化不對稱合成 ? ?◆現代催化體系和綠色合成新方法的開發
    ◆ 金屬與有機催化協同的催化體系應用 ? ?◆手性藥物的開發和天然產物策略全合成

     

    教育研究背景:

    ◆ 2010年3月-2012年09月,博士后, ? ? ?美國斯克普斯研究所 (TSRI)
    (導師:Carlos F. Barbas III教授)
    ◆ 2006年1月-2010年01月,博士研究生, ? 新加坡南洋理工大學(NTU)
    (導師:鐘國富教授)
    ◆ 2002年9月-2005年11月,碩士研究生, ? 廈門大學 (XMU)
    (導師:靳立人教授)

    工作經歷:

    2012.9-至今 南方科技大學化學系

     

    所獲榮譽:

    ◆ 2012年,中組部第四批“國家特聘專家(青年)”入選者
    ◆ 2013年,深圳市海外高層次人才“孔雀計劃”B類入選者
    ◆ 2009年,國家優秀自費留學生獎學金

     

    代表性研究成果:(獨立工作以前,只列第一作者,所有文章的影響因子都大于5.5)

    1. Tan, B.; Candeias, N.; Barbas III, C.R. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nature Chem. 2011, 3, 473-477.
    2. Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538-12541.
    3. Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rational Design Enables Amide Nucleophiles for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381-5385.
    4. Tan B.; Hernández-Torres, G.; Barbas III, C.F. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. J. Am. Chem. Soc. 2011, 131, 12354-12358.
    5. Tan, B.; Candeias, N.; Barbas III, C.F. J. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J. Am. Chem. Soc. 2011, 131, 4672-4675.
    6. Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758-761.
    7. Tan, B.; Zeng, X.; Chua, P. J.; Zhong, G. Rational Design of Domino Michael-Henry Reaction: Direct Construction of Bicyclo[3.2.1]octane Skeletons with Four Stereogeric Centers. Org. Lett. 2010, 12, 2682-2685.
    8. Tan, B.; Zhu, D.; Zhang, L.; Dai, L.; Chua, P. J.; Shi, Z.; Zeng, X; Zhong, G. Water More than Just a Green Solvent: A Stereoselective One-Pot Access to All Chiral Tetrahydronaphthalenes in Aqueous Media. Chem. Eur. J. 2010, 16, 3842-3848.
    9. Tan, B.; Zeng, X.; Leong, W. W. Y.; Shi, Z.; Barbas III, C.F.; Zhong, G. Core Structure-Based Design of a Novel Organocatalytic [3+2] Cycloaddition: Highly efficient and Stereocontrolled Synthesis of Spirocyclic Oxindoles. Chem. Eur. J. 2012, 18, 63-67.
    10. Tan, B.; Zhang, X.; Chua, P. J.; Zhong, G. Recyclable organocatalysis: highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins (Cover Article). Chem. Commun. 2009, 779-781
    11. Tan, B.; Zeng, X.; Lu, Y.; Chua, P. J.; Zhong, G. Rational Design of Organocatalyst: Highly Stereoselective Michael Addition of Cyclic Ketones to Nitroolefins. Org. Lett. 2009, 11, 1931-1933.
    12. Tan, B.; Chua, P. J.; Zeng, X.; Lu, M.; Zhong, G. A Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Cyclopentanes with Four Chiral Carbons by the Organocatalytic Domino Michael-Henry Reaction. Org. Lett. 2008, 10, 3489-3492.
    13. Tan, B.; Shi, Z.; Chua, P. J.; Zhong, G. Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes. Org. Lett. 2008, 10, 3425-3428.
    14. Tan, B.; Chua, P. J.; Li, Y.; Zhong, G. Organocatalytic Asymmetric Tandem Michael-Henry Reactions: A Highly Stereoselective Synthesis of Multifunctionalized Cyclohexanes with Two Quaternary Stereocenters. Org. Lett. 2008, 10, 2437-2440.

     

    代表性研究成果:(獨立工作以后從2013年7月至今)

    1. Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan,* Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201504640.
    2. Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*, Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201503207.
    3. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of ?Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.
    4. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*,Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.
    5. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*,and Xin-Yuan Liu* “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene” ?Angew. Chem. Int. Ed. 2014, 53, 11890.
    6. Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan* “Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Br?nsted Acid” Angew. Chem. Int. Ed. 2014, 53, 3684.
    7. Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.
    8. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589-1592.

    9. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds. Chem. Eur. J. 2015, 21, 6718.

    10. Lei Li, Jing-Yao Guo, Su Chen, Tao Wang, Bin Tan* and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett., 2014, 16, 6032.

    11. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.

    12. Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles” Org. Lett. 2014, 16, 2192.

    13. Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 2014, 16, 1000.

    14. Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu.* “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles” Org. Lett. 2014, 16, 504.

    15. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 2014, 20, 1332.

    16. Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan* and Carlos F. Barbas, III* “Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies”
    ACS Catal. 2014, 4, 743.

     

    項目基金

    1. 研究基金+廣東省配套經費(250萬);
    2.?南方科技大學引進學術人才科研啟動經費(620 + 100 萬)
    核心骨架結構導向的催化不對稱合成;
    3.?國家自然科學基金委青年面上項目(80萬)
    有機催化不對稱合成聯芳基軸手性化合物;
    4.?國家自然科學基金委青年基金項目(25萬)
    不對稱合成具有重要生物活性3,3′-四氫吡咯螺羥吲哚骨架結構;
    5.?深圳市科技創新委員會基礎研究項目(10萬)
    四氫吡咯螺羥吲哚衍生物的設計和催化不對稱合成以及抗癌活性的研究;
    6.?深圳市科技創新委員會基礎研究項目(30萬)
    基于重氮吲哚酮的催化不對稱合成及其產物的抗癌活性研究

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